Based on paralyzed and death time, zinc oxide (ZnO) nanoparticles (NPs) were preliminarily investigated for possible biological effectiveness of anthelmintic activity on Pheretima Posthuma. After synthesizing ZnO NPs by low-temperature precipitation method with slight modification, size, morphology, and shape evaluation of these nanoparticles were characterized by scanning electron microscopy and annealing temperature in the range 400-700C. In this anthelmintic assay, the paralyzed time (PT) was gradually shorter with the increase of the sample concentration, for instance, when high concentration (40mg/ml) sample was applied on adult worms the paralyzed time was 35.6 minutes only. The death time (DT) was 450 and 80 minutes when the sample concentration was 20 and 40 mg/ml respectively. These results were compared with albendazole as a reference showed PT and DT 378.6 and 402.3 minutes respectively, and showed maximum dose-dependent anthelmintic activity. Finally, at higher concentration paralytic effect (PE) was showed much earlier and subsequently, it is important to note that the time taken for death observation was shorter.

Gold and silver nanoparticles are easily synthesized and the most effective nanostructures in clinical practice. Their optical properties, ease of synthesis, colloidal stability and the ability to form any surface for easier conjugation with biological particles, the ability to individual multiple use, make them especially important in oncology. Gold and silver nanoparticles are capable of providing targeted drug delivery, which depends on the photothermal, photodynamic, and antiangiogenic properties of the metal. Due to their exceptional properties, these nanoparticles are considered as a potential tool for the diagnosis of various types of cancer and drug delivery. The non-toxic and non-immunogenic nature of gold and silver nanoparticles, as well as their high permeability and retention effect, provide additional advantages, allowing drugs to easily penetrate and accumulate at tumor sites. The effectiveness of precious metal nanoparticles as radiosensitizers, dose enhancers and contrast agents is gaining increasing recognition. An important problem associated with the use of biogenic metal nanoparticles is the study of their genotoxicity, since they play an important role in the initiation and progression of abnormalities, including genetic ones.

This paper offers a novel multiobjective approach – Multiobjective Ions Motion Optimization (MOIMO) algorithm stimulated by the movements of ions in nature. The main inspiration behind this approach is the force of attraction and repulsion between anions and cations. A storage and leader selection strategy is combined with the single objective Ions Motion Optimization (IMO) approach to estimate the Pareto optimum front for multiobjective optimization. The proposed method is applied to 18 different benchmark test functions to confirm its efficiency in finding optimal solutions. The outcomes are compared with three novel and well-accepted techniques in the literature using five performance parameters quantitatively and obtained Pareto fronts qualitatively. The comparison proves that MOIMO can approximate Pareto optimal solutions with good convergence and coverage with minimum computational time.

A new method for the direct oxidation of aromatic amines to azobenzenes employing aqueous tertiary-butyl hydrogen peroxide and potassium tertiary butoxide as an oxidant and base, respectively is described. The desired products are obtained in good yields. The developed protocol is associated with certain advantages for example free from any metal oxidants.

In MCDM problems, the decision maker is often ready to adopt the closest solution to the reference values in a choice or ranking problem. The reference values represent the desired results as established subjectively by the decision maker or determined through various scientific tools. In a criterion, the reference value could be the maximum value, the minimum value, or a specific value or range. Also, the acceptances degrees of ranges outside the reference may differ from each other in a criterion. Furthermore, measurements in a criterion may have been obtained with any of the nominal, ordinal, interval, and ratio scales. For the decision problems, including qualitative criteria, the solution cannot be achieved without scaling of criteria with the existing MCDM methods. The purpose of this study is to propose the Nearest Solution to References (REF) Method, a novel reference-based MCDM method, for the solution of decision problems having mixed data structure where references can be determined for criteria.

Past researches on 4-thiazolidinone nucleus have revealed the prominent potential of derivatives containing this nucleus to be developed as a potent therapeutic agent. Because of these biological activities, their structure-activity relationship has created an interest for medicinal chemists leading to the discovery of a number of lead molecules. This review highlights the routes for its synthesis and summarizes the past and recent studies on its biological activities to guide the medicinal chemists working on this nucleus in the development of clinically viable drugs.

The objective of this research is to determine the location for the dock and office of naval bases in Padang city of Indonesia. Following this objective, the Regional Government of Padang Mentawai Islands District provides 3 (three) alternative places namely in Semabuk Bay, Siuban Bay, and Semebai Bay for the location of dock and office of Naval Base. For the selection of Mentawai base, the method uses BORDA and PROMETHEE, since the methods can consider alternative evaluation based on factors that are both qualitative and quantitative. Based on the research of BORDA method calculation on 16 naval base selection criteria, it is found that criterion of Sailing Flow maintains the highest weight value that is equal to 10.9% and the lowest criterion weighted value belongs to criterion Political Condition for about 2%. For the results of ranking against the alternative using the Promethee method, the study obtains Semebai Bay as the best location to serve for the location of the base of the Mentawai Naval Base.

The challenge of improving construction safety performance is observed in many countries. Safety is considered by practitioners and researchers as an important topic in construction industry sites. Despite the findings of implementing safety programs, it is revealed that accidents and injuries are not perfectly reduced in construction projects. In the literature, authors tried to establish several frameworks and proposed methods to reach this objective by identifying the key factors affecting safety performance. The aim of this study is to present critical factors used in the implementation of safety programs and to explore their relationships using Interpretive Structural Modeling (ISM). Then, via ISM technique, the overall structure among factors was revealed. By using the Fuzzy MICMAC analysis, the factors were classified into four groups based on their driving power and dependence power. The results showed that “Safety Training” and “Management Commitment” have the most important impact on safety programs, but also it is very important to study the interactions among factors at different stages. This analysis offers key resources for practitioners and decision makers by analyzing the relationships between factors and its driving or dependence strength. These results shed lights on the effective development of measures to facilitate the implementation of safety programs in the construction sector.

The development of the shipbuilding industry is expected to meet the needs of the Indonesian Navy and the commercial vessels, and to support Indonesia's marine policy. The purpose of this study is to see the Shipbuilding industry Competitiveness, the influence of Technology Transfer to the Shipbuilding industry Competitiveness, and the influence of the industrial clusters on the Shipbuilding industry Competitiveness, as well as to analyze the institutional model of the Shipbuilding industry Competitiveness. This study uses the descriptive analysis, the Structural Equation Modeling (SEM) for the model causality testing, and the Interpretative Structural Modeling (ISM) for the institutional model of the competitiveness of the Shipbuilding Industry. This study uses the primary data, namely a survey of defense industry players, the national industry, the defense equipment users, the government institutions, the research institutes, and the universities that are determined purposively. ISM data are obtained from questionnaires and Forum Group Discussion (FGD) with 13 speakers representing academia, industry, and government. The results of the analysis of SEM state that the indicators on the industrial clusters, the competitiveness, and the technology transfer have a significant and real contribution to these variables. This research also shows that the industrial clusters and the technology transfer have a direct and significant effect on the competitiveness and the industrial clusters directly and significantly affect the technology transfer. However, the industrial clusters also have an indirect effect on competitiveness through the technology transfer to the shipbuilding industry. The results of the analysis of ISM conclude that the stakeholders involved have the greatest driving force, namely the Ministry of Defense and Ministry of State-Owned Enterprises, while the important factor affected by the stakeholders in strengthening the competitiveness of the shipbuilding industry is the Indonesian Navy Headquarters.

Due to the important environmental effects on human life and the conflict between the mining process and environmental factors, the enactment of protectionist environmental laws in the mineral industry has received extensive attention especially in countries with high mining potential. In this regard, using an extended fuzzy TOPSIS method, this study develops a novel conceptual framework to identify the key protection laws in Iran by considering the mineral successful laws and regulations in mineral-developed countries such as Australia, Chile, India, Turkey, Canada, South Africa, and China. This helps to apply the experiences of the abovementioned countries in resolving similar conflicts in Iran’s mineral industry. The key protection laws are selected based on their national and international environmental treaties, mines’ environmental protection laws, conflict solution methods, social responsibilities in mining activity, and laws for the abandoned mines. The proposed framework demonstrates that Iran’s mineral laws require revision and more transparency to avoid ambiguity and conflict with mineral property laws and governmental rights.