Gamification as a new concept uses game elements in a novel way to engage users of a non-gaming system and can be used in many domains within an enterprise, to implement the organizational processes with lower costs, higher quality or in a more efficient way. Although there are many researches on gamification but a few studies can be found in the organizational gamification and there are few research works about framework and methodology for designing and implementing organizational gamification in the literature. The purpose of this article is to provide a comprehensive methodology for the enterprise gamification. This research is an attempt to overcome the mentioned gap via presenting a methodology by applying some important issues including organizational, humanity and gamification aspects together to design and implement customized enterprise gamification solutions through reviewing the related literature and experts’ commentaries. The evaluation of the methodology showed that it is an appropriate and perfect way to design gamification solutions in an organization, besides the enterprise needs to provide the necessary conditions for its implementation. This paper forwards an important debate on a comprehensive methodology for applying enterprise gamification, which explains how to properly use gamification in enterprises to increase productivity and better communication with employees, and thus contributes to literature on internal and enterprise gamification.

Due to the new hopes for treatment of multiple sclerosis (MS) diseases by Teriflunomide (TFN), in this project, a cheap, robust, and fully validated method has been developed both for determination of assay content in API (active pharmaceutical ingredient), and for related impurities analysis (RIA). To operate the method, a common C18, end-capped (250 × 4.6) mm, 5µm liquid chromatography column, was applied. The mobile phase A was prepared by dissolving 2.74 g (20mM) of PDP (potassium dihydrogen phosphate) and 3.72 g (50mM) of PC (potassium chloride) in water (1000 mL). Then, pH was adjusted to 3.0 by adding OPA (ortho-phosphoric acid) 85%; while, the mobile phase B was acetonitrile (ACN) (100%). In order to confirm the experimental data about the λmax of TFN, we have used the Born-Oppenheimer molecular dynamics (BOMD) simulations, quantum mechanics (QM), and TD-DFT calculations. According to the results, the method showed a high level of suitability, specificity, linearity, accuracy, precision, repeatability, robustness, and reliable detection limit.

The study proposes a set of enablers of the consumer sustainable organic food consumption and detects the interrelationship between these attributes. This paper adopts the fuzzy set theory and decision-making trial and evaluation to explore the interrelationship between attributes, including consumer demographic aspect, psychological aspect, social-level aspect and stakeholder impact being explained through 13 criteria and being assessed by experts in the industry. The findings show that stakeholder impact and demographic aspect belong to a causal group and impact the other two aspects. The six most important attributes affecting sustainable consumption of organic foods are support and guidance from government support, mass media, education and research institutions, educational level, income status and consumer age. The study grants an alternative approach for sustainable consumption theory through providing a fuzzy-set theory for multiple criteria decisions making in sustainable consumption of organic foo

Due to the new hopes for treatment of multiple sclerosis (MS) diseases by Teriflunomide (TFN), in this project, a cheap, robust, and fully validated method has been developed both for determination of assay content in API (active pharmaceutical ingredient), and for related impurities analysis (RIA). To operate the method, a common C18, end-capped (250 × 4.6) mm, 5µm liquid chromatography column, was applied. The mobile phase A was prepared by dissolving 2.74 g (20mM) of PDP (potassium dihydrogen phosphate) and 3.72 g (50mM) of PC (potassium chloride) in water (1000 mL). Then, pH was adjusted to 3.0 by adding OPA (ortho-phosphoric acid) 85%; while, the mobile phase B was acetonitrile (ACN) (100%). In order to confirm the experimental data about the λmax of TFN, we have used the Born-Oppenheimer molecular dynamics (BOMD) simulations, quantum mechanics (QM), and TD-DFT calculations. According to the results, the method showed a high level of suitability, specificity, linearity, accuracy, precision, repeatability, robustness, and reliable detection limit.

The healthcare system is a vital element for any community, as it extremely affects the socio-economic development of any country. The current study aims to assess the performance of the healthcare systems of the countries above fifty million citizens in facing the spread of the COVID-19 pandemic since late December 2019. For this purpose, seven scenarios were adopted via the DEA methodology with six variables, which are the number of medical practitioners (doctors and nurses), hospital beds, Conducted Covid-19 tests, affected cases, recovered cases, and death cases. To shed light on the relative efficiency of drivers, the Tobit analysis was used. Besides, the study carried out various statistical tests for the DEA models' findings to validate the choice of the variables and the obtained scores. The DEA results reveal that less than half of the considered countries are relatively efficient. Moreover, the Tobit regression analysis showed that the main impact on the efficiency scores was due to the number of affected and recovered cases. Finally, the results of the tests of Spearman, Mann-Whitney U, and Kruskal-Wallis H indicate the internal validity and robustness of the chosen DEA models. The current study findings raise important implications, which can be helpful for decision makers regarding continuous improvement of performance, in which the findings assert the importance of achieving the best practices regarding relative efficiency through the linkage between the healthcare systems’ resources, and the needed outputs.

A sequence of pyrano[2, 3-c]pyrazoles was constructed through promoting an eco-friendly, green, and efficient approach. M1-M25 derivatives were developed by a base-catalyzed one-pot reaction involving application of hydrazine hydrate 96%, β-keto ester as ethyl acetoacetate or diethyl malonate, aryl/heteroaryl aldehyde or isatin, and enolizable active methylene compounds with isolation of unexpected compound M2. Further on, intramolecular cyclization of compounds M10, M13 with formic acid, acetic anhydride, and formamide leads to the corresponding pyrimidine derivatives M26-M31. Afterwards, the antimicrobial activity of the compounds was evaluated and fortunately, the vast majority of the compounds showed outstanding anti-bacterial results. Besides, the potential mode of action of the synthesized compounds was determined by employing a molecular-docking study against penicillin-binding protein implicated in anti-bacterial action. Compound M21 was one of the most promising anti-bacterial agents with potential binding affinity against the penicillin-binding protein. This study shed light on novel compounds for further antimicrobial drug development.

Flow shop scheduling problems with rudimentary criteria of minimum makespan are the most important investigated problems in the field of scheduling. Generally during the process of generating an optimal sequence, multiple partial sequences claiming the optimal value of makespan are observed. In this paper a novel tie-breaking rule to select one of the best optimal sequences out of all possible partial sequences is developed which then applied to Nawaz-Enscore-Ham (NEH) heuristic to solve the scheduling problems in permutation flowshop without increasing the computational complexity. The performance of proposed heuristic is tested with other existing tie-breaking heuristics of similar complexity over Taillard and VRF's instances. Computational results reveal that in terms of solution quality, the proposed heuristic outperforms over the other NEH based heuristics of the same complexity reported in literature.

The development of the Islamic State (IS) in Southeast Asia creates changes in the social order in a direct and indirect manner. This study aims to identify the factors that influence the development of the Islamic State (IS) and analyze the influence of its development on social vulnerability in Southeast Asia. This study employed a mixed-method supported by the Interpretive Structural Modeling (ISM), Analytical Hierarchy Process (AHP), and System Dynamics (SD). Based on the results of research from relevant experts, this study uncovered seven the most dominant and structured problems. Furthermore, there are fourteen elements related to the social vulnerability of the Islamic State (IS) in Southeast Asia. The social vulnerability value is 0.01 and is categorized as Low Vulnerability. The aspects that influence the development of Islamic State indicate that the existing social system in Southeast Asia is strong enough in encountering the influence of ideology and the development of the Islamic State.

Sulfonamides are a very good antibacterial agent that targets essential bacterial enzymes specifically DNA gyrase. The objective of the present work was to investigate the molecular docking of the (4-(tert-butyl)-N,N-diethylbenzenesulfonamide) with the DNA gyrase of S. aureus. The energy-free topoisomerase activity of the A subunit, which breaks the DNA, is inhibited by 4-quilones such as nalidixic acid and ciprofloxacin. The energy transducing activity of the B subunit is inhibited by novobiocin and other coumarin antibiotics. Single crystal X-ray diffractometer study was carried out to understand the structure, physical and chemical reactive parameters, the title compound is crystallized under monoclinic crystal system with the space group of P21/C. To understand the behaviour of the title compound in living organism, Absorption, Distribution, Metabolism, Excretion analysis was done using Swiss ADME and Osiris data warrior tool. Further, Toxicity of the title compound was predicted by using PKCSM online software.

In this study, under the carbon cap-and-trade mechanism, the ordering cost presents a stepwise function for ordering quantity, and the optimal economic ordering quantity model aims to explore the manufacturer's total cost minimization in the finite planning horizon, in combination with the actual situation that the product will produce carbon emissions during transportation and storage. The economic order quantity (EOQ) model with stepwise ordering cost is applicable to the decision environment in which goods are utilized by sea, by rail or by air (e.g., the order cost is charged in addition to the basic fixed cost, the importer of raw materials will pay an additional freight related to delivery, such as the rent for the use of container numbers.). A heuristic algorithm is also proposed to analyze the relevant properties of the optimal solution of the model and to solve the optimal order times and quantities of the manufacturer under the constraint of carbon policy.We further compared the optimal order times with the case without carbon constraint and the order times corresponding to the manufacturer's realization of the minimum carbon emission, and obtained the conditions for the manufacturer to achieve low cost and low emission under the carbon policy.Finally, the theoretical results of the model are verified by numerical examples,and the influence of relevant parameters on the inventory strategy of manufacturers is discussed. The results show that under the carbon cap-and-trade policy, there is an optimal ordering strategy that minimizes the total cost of the manufacturer in the finite horizon. When the demand of the manufacturer is under finite horizon and the carbon policy is equal to the specific multiplier of orders, the manufacturer can achieve a win-win result of low cost and low emissions.