A series of benzofuran derivatives compounds have been designed and synthesized. Here, Benzofuran linked with pyridinone compounds is reported. The desired compounds were prepared by using 2-nitrosalisaldehydnitrile (1). After, this is treated with chloroacetone, which results in the formation of 1-(3-amino-5-nitro-1-benzofuran-2-yl) ethanone (2). Later the 3a-b is produced by a reaction of acetylation and benzylation on compound 2 respectively. The alkylation of compounds 4a-b react with sodium hydroxide, we get new pyridinone compounds. All the synthesized compounds were characterized by IR, 1H NMR, and GCM. Further, these have been screened for their antimicrobial, and antioxidant activity. Along with this activity reference we design drug discovery of Molecular docking study by using different computational software.

Wide range of 2,4,5-trisubstituted imidazoles were synthesized using eco-friendly, readily available, inexpensive Zn(OAc)2•2H2O (5 mol%) under solvent-free conditions in moderate to excellent yields by condensation from aldehyde, ammonium acetate and benzil at 70 0C. The optimized reaction parameters were successfully applied for the synthesis of divergent 1,2,4,5-tetrasubstitued imidazoles using aromatic amine as fourth component. All the imidazole derivatives were sufficiently characterized by IR, NMR and Mass spectral analyses.

This research examined the relationships between Organizational Commitment, Organizational Citizenship Behavior (OCB), the Supply Chain, and Green Hospital practices in a healthcare setting. A cross-sectional study was conducted using self-reported data from healthcare employees. Structural equation modeling was employed to analyze the relationships and mediation effects. The study confirmed that Organizational Commitment positively impacts the Supply Chain and Green Hospital practices. Similarly, Organizational Citizenship Behavior significantly influences the Supply Chain and Green Hospital initiatives. The Supply Chain was found to have a positive impact on Green Hospital practices and served as a mediator in the relationships between Organizational Commitment and Green Hospital and Organizational Citizenship Behavior and Green Hospital. The research provides valuable insights for healthcare organizations seeking to enhance their sustainability efforts. Fostering Organizational Commitment and Organizational Citizenship Behavior among employees can contribute to more efficient supply chain operations and environmentally responsible practices. The study underscores the crucial role of supply chain management in translating commitment and proactive behaviors into tangible sustainability initiatives. The research is context-specific, and using self-reported data and a cross-sectional design may limit generalizability. Future studies should explore these relationships in diverse settings and consider longitudinal or mixed-method approaches.

Herbicides used on a regular basis could endanger non-target species like earthworms. The aim of this work was to test the toxic effect of atrazine and metribuzin on Aporrectodea caliginosa by filter paper contact and soil mixing techniques. Atrazine had the highest intrinsic toxicity to earthworms, with LC50 of 0.026 µg mL-1 after 72 hr of treatment. While the LC50 of metribuzin was 0.063 µg mL-1 after 72 hr by filter paper contact test. LC50 was reduced from 11.121 to 3.118 and 164.824 to 19.113 μg g soil-1 in clay soil, from 32.221 to 17.33 and 324.141 to 41.028 μg g soil-1 in soil (1:1) and from 41.234 to 30.804 and 462.255 to 70.902 μg g soil-1 in sandy clay loam soil of atrazine and metribuzin after 5 and 10 day. Generally, atrazine is more toxic than metribuzin in both tests.

In the present work the synthesis of 4-phenyl-2, 6-di (thiazol-2-yl) pyridine copper chloride (abbreviated as Cu-DTPy) complex using copper (II) chloride and 2, 6-di (thiazol-2-yl) pyridine has been carried out. The complex has been specified by UV-Vis, FT-IR, CHNS and ESI-MS methods of analysis. The synthesized copper complex has been used as catalyst in the oxidation of p-aminophenol using hexacyanoferrate (III) ions as an oxidant in aqueous alkaline medium by kinetic-spectrophotometric method. This experimental work was carried out at optimum pH 11.0 and temperature 25ºC. The variation of effect of concentration of p-aminophenol (abbreviated as PAP), hexacyanoferrate (III) ions, and Cu-DTPy catalyst on reaction rate has been studied. Thermodynamic parameters such as free energy of activation, activation energy, enthalpy and frequency factor have been evaluated with the change in rate of the reaction at four disparate temperatures i.e. 25-40ᵒC. The oxidation products have been identified by FT-IR and ESI-MS spectroscopic analytical techniques. The major product of this reaction is NN’-bis-(p-hydroxyphenyl)-2-hydroxy-5-amino-1,4-benzoquinone di-imine. Thus, this method is highly efficient and environmentally safe to remove PAP from polluted water resources.

This study aims to present further evidence of cost stickiness by employing Selling, General, and Administrative (SG&A) costs. It also provides empirical evidence on the effect of audit committee meetings and audit quality on cost stickiness. The study used data from listed companies on the Saudi Arabian stock exchange during 2015–2019. Based on pooled panel data regression, the study proves that the SG&A costs are sticky. The results show the level of SG&A costs increases more with an increase in sales revenue (activity) while it decreases less with an equivalent reduction in sales revenue (activity). Also, this study finds that the frequency of audit committee meetings decreases the magnitude stickiness of SG&A costs, which supports the view that frequent meetings of AC significantly enhance its overseeing function and effectiveness. The study further reveals that audit quality “by BIG4 audit firms” is not related to reduced cost stickiness. This result implies that there is no difference in CS between companies audited by BIG4 or by non-BIG4. In general, the research highlights the importance of AC diligence (i.e., meetings) in improving its effectiveness and controlling management’s discretions affecting the cost structure in the context of sticky cost behavior.

A review of the literature, multiple authors in order to systematize information on the effect of temperature in the range of 25-42 ° C on blood proteins, to conduct further studies of the effect of temperature on the stability of fibrinogen molecules in aqueous solution. Study of works on the determination of conformation and stability of protein molecules in the temperature range of living organisms.

Fuel availability is essential in supporting the sustainable economic growth of a country. The manufacturing industry, transportation activities, and shipping products between regions are the primary sectors that require a sustainable fuel supply. The fuel station contributes to distributing and delivering fuel in serving the demand for the fuel. This study investigates supplier competency's role in supporting fuel station business performance through supplier integration, vendor-managed inventory, and supply chain collaboration. The research surveyed 71 fuel stations in Timor Leste using a questionnaire designed with a five-point Likert scale. The questionnaires are distributed to supervisors or higher positions at fuel stations by distributing questionnaires by direct delivery and also through Google Forms for areas far away in downtown Timor Leste. Data from respondents were analyzed using smartPLS software version 4.0. The results found that supplier competency positively impacts supplier integration, vendor-managed inventory, and supply chain collaboration. Moreover, supplier integration positively impacts vendor-managed inventory, supply chain collaboration, and business performance. Vendor-managed inventory fuel station sites can have an impact on improving supply chain collaboration and business performance. In addition, supply chain collaboration between vendors and fuel stations in Timor Leste enables continuous business performance improvement. This research paves the way for supervisors, managers, and fuel station top management to collaborate with suppliers in maintaining inventory levels and forecasting the supply and demand for fuel procurement requirements. Finally, this research contributes to the theory of inventory optimization and supply chain performance.

The soil type and temperature are considered important parameters that can influence the rates and equilibria of different environmental processes. Therefore, the adsorption and desorption isotherms of fipronil in clay loam, clay, sandy loam, sandy clay loam, sand and loamy sand soils at 25 and 50˚C was studied. The amount of fipronil adsorbed and desorbed by different soils was significantly influenced by the temperature. Adsorption was higher in clay loam, clay, sandy clay loam and sandy soil at 25°C, while sand soil and loamy sand soil at 50°C. The non-desorbed amount was greater at 25°C in different types of soil except for clay loam soil. The negative ΔG˚ indicated that the adsorption/desorption in different types of soil was spontaneous at different temperatures. The value of standard enthalpy change (ΔH˚) was positive in clay soil, sandy loam soil, sandy clay loam soil and loamy sand soil for adsorption and sandy loam soil, sand soil and loamy sand soil for desorption. Moreover, the standard entropy change (ΔS˚) was negative in soils for adsorption and desorption isotherms except clay loam soil. Adsorption and desorption isotherms trends as well as the values of the correlation coefficients indicated that the adsorption and desorption isotherms of fipronil in tested soils were fitted to the Freundlich model because the correlation coefficient is very close to 0.999.

In Egypt, the request for salt fish products has been increasing during many feasts because it is one of Egypt's favorite foods. It has been reported that in certain seasons, these products cause toxicity and even death. Most fish poisonings around the world are known to be caused by elevated histamine levels. Thus, the study assessed the histamine levels of herring and fesikh samples available on the market and established the safety of these products with recommendations for various treatments that may inhibit the production of histamine in herring and fesikh through bacteria and enzyme production. Before manufacturing herring and fesikh, the fresh fish is soaked for one hour in a modified pH solution of 4 by vinegar with the addition of natural substances individually or in combination (such as garlic, onion, hot pepper, or aloe vera) or some chemicals singly (such as edta, nisin, h2o2, formic acid, and so2). The levels of histamine in herring (111 to 138 mg/kg) and fesikh (214 to 279 mg/kg) were unsafe in marketable samples. The histamine levels of herring and fesikh in proposed treatments were safe since they did not exceed 26 mg/kg after 30 days of cold storage for herring or 45 mg/kg after maturity of fesikh. The proposed treatments enhanced greatly herring and fesikh organoleptic qualities, especially those containing natural ingredients, such as garlic, hot pepper, or their mixture beside onion, which are more accepted treatments.